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Tschöp, M.H. ; Castañeda, T.R.* ; Joost, H.G.* ; Thöne-Reineke, C.* ; Ortmann, S.* ; Klaus, S.* ; Hagan, M.M.* ; Chandler, P.C.* ; Oswald, K.D.* ; Benoit, S.C.* ; Seeley, R.J.* ; Kinzig, K.P.* ; Moran, T.H.* ; Beck-Sickinger, A.G.* ; Koglin, N.* ; Rodgers, R.J.* ; Blundell, J.E.* ; Ishii, Y.* ; Beattie, A.H.* ; Holch, P.* ; Allison, D.B.* ; Raun, K.* ; Madsen, K.* ; Wulff, B.S.* ; Stidsen, C.E.* ; Birringer, M.* ; Kreuzer, O.J.* ; Schindler, M.* ; Arndt, K.* ; Rudolf, K.* ; Mark, M.* ; Deng, X.Y.* ; Whitcomb, D.C.* ; Halem, H.* ; Taylor, J.* ; Dong, J.* ; Datta, R.* ; Culler, M.* ; Craney, S.* ; Flora, D.* ; Smiley, D.* ; Heiman, M.L.* ; Withcomb, D.C.*

Physiology: Does gut hormone PYY3-36 decrease food intake in rodents?

Nature 430, 1 p following 165; discussion 2 (2004)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.
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Publication type Article: Journal article
Document type Letter to the Editor
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Quellenangaben Volume: 430, Issue: 6996, Pages: 1 p following 165; discussion 2 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)