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Open Access Green as soon as Postprint is submitted to ZB.
Obesity and the neuroendocrine control of energy homeostasis: The role of spontaneous locomotor activity.
J. Nutr. 135, 1314-1319 (2005)
Obesity represents one of the most urgent global health threats as well as one of the leading causes of death throughout industrialized nations. Efficacious and safe therapies remain at large. Attempts to decrease fat mass via pharmacological reduction of energy intake have had limited potency or intolerable side effects. Increasingly widespread sedentary lifestyle is often cited as a major contributor to the increasing prevalence of obesity. Moreover, low levels of spontaneous physical activity (SPA) are a major predictor of fat mass accumulation during overfeeding in humans, pointing to a substantial role for SPA in the control of energy balance. Despite this, very little is known about the molecular mechanisms by which SPA is regulated. The overview will attempt to summarize available information on neuroendocrine factors regulating SPA.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
0022-3166
e-ISSN
1541-6100
Journal
Journal of Nutrition
Quellenangaben
Volume: 135,
Issue: 5,
Pages: 1314-1319
Publisher
American Society for Nutrition
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)