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The many faces of ghrelin: New perspectives for nutrition research?
Br. J. Nutr. 93, 765-771 (2005)
The appetite-modulating peptide ghrelin is predominantly produced and secreted by the stomach and shows a strong growth hormone-releasing activity, which is mediated by the activation of the so-called growth hormone secretagogue type 1a receptor. Ghrelin is involved in the regulation of energy balance by increasing food intake and reducing fat utilization. Additionally, it stimulates lactotroph and corticotroph function, influences the pituitary gonadal axis, inhibits pro-inflammatory cytokine expression, controls gastric motility and acid secretion and influences pancreatic exocrine and endocrine function, as well as impacting on glucose metabolism. This review summarizes the known functions of ghrelin and its role in the regulation of the gut-brain axis.
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Publication type
Article: Journal article
Document type
Review
Language
english
Publication Year
2005
HGF-reported in Year
2005
ISSN (print) / ISBN
0007-1145
e-ISSN
1475-2662
Journal
British Journal of Nutrition
Quellenangaben
Volume: 93,
Issue: 6,
Pages: 765-771
Publisher
Cambridge Univ. Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
PubMed ID
16022744
Erfassungsdatum
2020-02-20