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Open Access Green as soon as Postprint is submitted to ZB.
Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development.
Genesis 47, 697-707 (2009)
Periphilin is involved in multiple processes in vivo. To explore its physiological role from an organismic perspective, we generated mice with a gene trap insertion in the periphilin-1 gene. Based on beta-gal reporter activity, a widespread periphilin expression was evident, especially in the developing somites and limbs, the embryonic nervous system, and the adult brain. In accordance with this broad expression, homozygous deficiency of periphilin was lethal in early embryogenesis. Mice with a heterozygous deficiency did not show any abnormalities of brain morphology and function, neither histologically nor regarding the transcriptome. Interestingly, the reduction of the periphilin-1 gene dosage was compensated by an increased expression of the remaining wild-type allele in the brain. These results point to an indispensable function of periphilin during murine development and an important role in the nervous system, reflected by a strong and tightly regulated expression in the murine brain.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
periphilin; knockout mice; gene trap; microarray analysis; compensatory gene expression; neurobiology
ISSN (print) / ISBN
1526-954X
e-ISSN
1526-968X
Quellenangaben
Volume: 47,
Issue: 10,
Pages: 697-707
Publisher
Wiley
Publishing Place
Hoboken
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)