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Simon, F.* ; Schwenk-Zieger, S.* ; Becker, S.* ; Unger, K. ; Gires, O. ; Baumeister, P.

Cigarette smoke reduces the efficacy of cisplatin in head and neck cancer cells - role of ABCG2.

Anticancer Res. 40, 1277-1284 (2020)
Postprint DOI PMC
Open Access Green
Background/Aim: We evaluated the influence of smoking on head and neck squamous cell carcinomas (HNSCC), which are in their majority tobacco-driven. Tobacco smoke is expected to influence the expression of ABCG2-transporters involved in multidrug resistance. The aim of the study was to evaluate the effect of cigarette smoke condensate (CSC) on ABCG2 expression on HNSCC cells, to demonstrate the adverse effects of cigarette smoke during anticancer treatment in vitro and to assess the prevalence of ABCG2 expression in HNSCC. Materials and methods: HNSCC cell lines were treated with CSC and basal and induced ABCG2 expression was examined. The impact of CSC on cellular viability/proliferation during cytotoxic drug treatment was also evaluated. ABCG2 expression levels in HNSCC were correlated with the smoking history of patients. Results: HNSCC cells showed low basal ABCG2 expression. CSC treatment resulted in a threefold increase in the expression of ABCG2 and in resistance to cisplatin. Tumor samples of never smokers showed significantly higher ABCG2 expression compared to ever smokers. ABCG2 expression correlated with pack years of cigarette consumption. Conclusion: Tobacco consumption is linked to an inducible and increased ABCG2 protein expression and has an impact on drug resistance.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Abcg2 ; Hnscc ; Csc ; Cisplatin ; Pica ; Fadu ; Cigarette Smoke; Human-papillomavirus; Transporter; Expression; Carcinoma; Risk
ISSN (print) / ISBN 0250-7005
e-ISSN 1791-7530
Journal Anticancer Research
Quellenangaben Volume: 40, Issue: 3, Pages: 1277-1284 Article Number: , Supplement: ,
Publisher International Institute of Anticancer Research
Publishing Place Editorial Office 1st Km Kapandritiou-kalamou Rd Kapandriti, Po Box 22, Athens 19014, Greece
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Radiation Cytogenetics (ZYTO)
CCG Personalized Radiotherapy in Head and Neck Cancer (KKG-KRT)