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Ovsepian, S.V. ; Jiang, Y.* ; Sardella, T.C.P.* ; Malekzadeh Najafabadi, J. ; Burton, N.C.* ; Yu, X.* ; Ntziachristos, V.

Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging.

Photoacoustics 17:100153 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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To date, the vast majority of intra-vital neuroimaging systems applied in clinic and diagnostics is stationary with a rigid scanning element, requires specialized facilities and costly infrastructure. Here, we describe a simple yet radical approach for optoacoustic (photoacoustic) brain imaging in vivo using a light-weight handheld probe. It enables multispectral video-rate visualization of hemoglobin gradient changes in the cortex of adult rats induced by whisker and forelimb sensory inputs, as well as by optogenetic stimulation of intra-cortical connections. With superb penetration and molecular specificity, described here in method holds major promises for future applications in research, routine ambulatory neuroimaging, and diagnostics.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Neuroimaging ; Hemoglobin Gradients ; Brain ; Optogenetic Stimulation ; Photoacoustic ; Handheld Probe ; Barrel Cortex; Tomography Msot; Brain; Feasibility
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2213-5979
Journal Photoacoustics
Quellenangaben Volume: 17, Issue: , Pages: , Article Number: 100153 Supplement: ,
Publisher Elsevier
Publishing Place Hackerbrucke 6, 80335 Munich, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
DOI 10.1016/j.pacs.2019.100153
WOS ID WOS:000522738900004
Scopus ID 85080060596
PubMed ID 32154103
Erfassungsdatum 2020-03-24
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