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Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging.
Photoacoustics 17:100153 (2020)
To date, the vast majority of intra-vital neuroimaging systems applied in clinic and diagnostics is stationary with a rigid scanning element, requires specialized facilities and costly infrastructure. Here, we describe a simple yet radical approach for optoacoustic (photoacoustic) brain imaging in vivo using a light-weight handheld probe. It enables multispectral video-rate visualization of hemoglobin gradient changes in the cortex of adult rats induced by whisker and forelimb sensory inputs, as well as by optogenetic stimulation of intra-cortical connections. With superb penetration and molecular specificity, described here in method holds major promises for future applications in research, routine ambulatory neuroimaging, and diagnostics.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Neuroimaging ; Hemoglobin Gradients ; Brain ; Optogenetic Stimulation ; Photoacoustic ; Handheld Probe ; Barrel Cortex; Tomography Msot; Brain; Feasibility
ISSN (print) / ISBN
2213-5979
Journal
Photoacoustics
Quellenangaben
Volume: 17,
Article Number: 100153
Publisher
Elsevier
Publishing Place
Hackerbrucke 6, 80335 Munich, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)