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Dalenberg, J.R.* ; Patel, B.P.* ; Denis, R.* ; Veldhuizen, M.G.* ; Nakamura, Y.* ; Vinke, P.C.* ; Luquet, S.* ; Small, D.M.

Short-term consumption of sucralose with, but not without, carbohydrate impairs neural and metabolic sensitivity to sugar in humans.

Cell Metab. 31, 493-502 (2020)

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There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie "diet'' drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in healthy human participants, an effect that correlates with reductions in midbrain, insular, and cingulate responses to sweet, but not sour, salty, or savory, taste as assessed with fMRI. Taste perception was unaltered and consuming the carbohydrate alone had no effect. These findings indicate that consumption of sucralose in the presence of a carbohydrate rapidly impairs glucose metabolism and results in longer-term decreases in brain, but not perceptual sensitivity to sweet taste, suggesting dysregulation of gut-brain control of glucose metabolism.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Diabetes ; Fmri ; Glucose Tolerance ; Indirect Calorimetry ; Insula ; Low-calorie Sweetener ; Midbrain ; Obesity ; Taste Perception; High-intensity Sweeteners; Low-calorie Sweeteners; Weight-gain; Glucose-homeostasis; Insulin-resistance; Body-weight; Nonnutritive Sweeteners; Artificial Sweetener; Hormonal Responses; Taste Receptor

ISSN (print) / ISBN 1550-4131

e-ISSN 1932-7420

Journal Cell Metabolism

Quellenangaben Volume: 31, Issue: 3, Pages: 493-502

Publisher Elsevier

Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)