PuSH - Publication Server of Helmholtz Zentrum München

Kataka, E.* ; Zaucha, J.* ; Frishman, G. ; Ruepp, A. ; Frishman, D.*

Edgetic perturbation signatures represent known and novel cancer biomarkers.

Sci. Rep. 10:4350 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Isoform switching is a recently characterized hallmark of cancer, and often translates to the loss or gain of domains mediating protein interactions and thus, the re-wiring of the interactome. Recent computational tools leverage domain-domain interaction data to resolve the condition-specific interaction networks from RNA-Seq data accounting for the domain content of the primary transcripts expressed. Here, we used The Cancer Genome Atlas RNA-Seq datasets to generate 642 patient-specific pairs of interactomes corresponding to both the tumor and the healthy tissues across 13 cancer types. The comparison of these interactomes provided a list of patient-specific edgetic perturbations of the interactomes associated with the cancerous state. We found that among the identified perturbations, select sets are robustly shared between patients at the multi-cancer, cancer-specific and cancer subtype specific levels. Interestingly, the majority of the alterations do not directly involve significantly mutated genes, nevertheless, they strongly correlate with patient survival. The findings (available at EdgeExplorer: "http://webclu.bio.wzw.tum.de/EdgeExplorer") are a new source of potential biomarkers for classifying cancer types and the proteins we identified are potential anti-cancer therapy targets.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Protein-interaction Networks; Inhibits Tumor-growth; Somatic Mutations; Down-regulation; R-package; Database; Driver; Tissue; Genes; Landscape
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: 4350 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)