PuSH - Publication Server of Helmholtz Zentrum München: Association between arsenic exposure and biomarkers of type 2 diabetes mellitus in a Croatian population: A comparative observational pilot study.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Lucio, M. ; Barbir, R.* ; Vučić Lovrenčić, M.* ; Canecki Varžić, S.* ; Ljubić, S.* ; Smirčić Duvnjak, L.* ; Šerić, V.* ; Milić, M.* ; Tariba Lovaković, B.* ; Krivohlavek, A.* ; Vinković Vrček, I.* ; Michalke, B.

Association between arsenic exposure and biomarkers of type 2 diabetes mellitus in a Croatian population: A comparative observational pilot study.

Sci. Total Environ. 720:137575 (2020)

Postprint

DOI

PMC

Abstract
Metrics
Extra information

Chronic exposure to high inorganic As levels in drinking water has been related to many diseases, including type 2 diabetes mellitus (T2D). The association with low and moderate As levels, however, remains controversial and has yet not been studied in European populations.This study aimed to investigate possible association between As exposure and biomarkers of T2D in Croatian population. Observation recruited 86 adults from Eastern Croatia, where groundwater is contaminated with inorganic As, and 116 adults from Western Croatia, where As levels in drinking water are low. Both populations were divided in patient groups (T2D or prediabetes) and healthy controls. Exposure was assessed by determining total As in blood and urine and As metabolites in urine.Eastern Croatian population had a significantly higher content of As in urine than Western, whereas the opposite was true for arsenobetain. Total As and As metabolites in urine positively correlated with hemoglobin A1c (HbA1c) and negatively with albuminuria.This study provides important preliminary data on the levels of As in urine and blood and their association with biomarkers of T2D in Croatian population exposed to low or moderate levels of As through drinking water as a solid basis for further research of the pathophysiological effects of such As exposure on the status and complications of diabetes.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Arsenic Exposure ; Type 2 Diabetes Mellitus ; Drinking Water ; Biomarkers Of T2d; Drinking-water; Low-level; Prevalence; Groundwater; Homeostasis; Secretion; Region; Urine; Risk

ISSN (print) / ISBN 0048-9697

e-ISSN 1879-1026

Journal Science of the Total Environment, The

Quellenangaben Volume: 720, Article Number: 137575

Publisher Elsevier

Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit BioGeoChemistry and Analytics (BGC)