PuSH - Publication Server of Helmholtz Zentrum München: High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Haedicke, K.* ; Agemy, L.* ; Omar, M. ; Berezhnoi, A. ; Roberts, S.* ; Longo-Machado, C.* ; Skubal, M.* ; Nagar, K.* ; Hsu, H.T.* ; Kim, K.* ; Reiner, T.* ; Coleman, J.* ; Ntziachristos, V. ; Scherz, A.* ; Grimm, J.*

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies.

Nat. Bio. Eng. 4, 286-297 (2020)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

The monitoring of vascular-targeted therapies using magnetic resonance imaging, computed tomography or ultrasound is limited by their insufficient spatial resolution. Here, by taking advantage of the intrinsic optical properties of haemoglobin, we show that raster-scanning optoacoustic mesoscopy (RSOM) provides high-resolution images of the tumour vasculature and of the surrounding tissue, and that the detection of a wide range of ultrasound bandwidths enables the distinction of vessels of differing size, providing detailed insights into the vascular responses to vascular-targeted therapy. Using RSOM to examine the responses to vascular-targeted photodynamic therapy in mice with subcutaneous xenografts, we observed a substantial and immediate occlusion of the tumour vessels followed by haemorrhage within the tissue and the eventual collapse of the entire vasculature. Using dual-wavelength RSOM, which distinguishes oxyhaemoglobin from deoxyhaemoglobin, we observed an increase in oxygenation of the entire tumour volume immediately after the application of the therapy, and a second wave of oxygen reperfusion approximately 24 h thereafter. We also show that RSOM enables the quantification of differences in neoangiogenesis that predict treatment efficacy.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

18.952

3.862