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Open Access Green as soon as Postprint is submitted to ZB.
Large animal models of diabetes.
In: Animal Models of Diabetes. Berlin [u.a.]: Springer, 2020. 115-134 (Methods Mol. Biol. ; 2128)
Safe and reliable large animal diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents but is often critiqued in higher animals due to reduced efficacy, relevant side effects, and inadequate mortality rate. In this chapter, we aim to describe both pharmacological and surgical approaches for reproducible and safe diabetes models in minipigs and primates. In addition, genetically modified pig models for diabetes research are described.
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Publication type
Article: Edited volume or book chapter
Keywords
Diabetes Induction ; Diabetes Model ; Pancreatectomy ; Pig Model ; Primate Model ; Streptozotocin
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Book Volume Title
Animal Models of Diabetes
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 2128,
Pages: 115-134
Publisher
Springer
Publishing Place
Berlin [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)