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Hasan, S.S.* ; Jabs, M.* ; Taylor, J.* ; Wiedmann, L.* ; Leibing, T.* ; Nordström, V.* ; Federico, G.* ; Roma, L.P.* ; Carlein, C.* ; Wolff, G. ; Ekim-Üstünel, B. ; Brune, M.* ; Moll, I.* ; Tetzlaff, F.* ; Gröne, H.J.* ; Fleming, T.* ; Géraud, C.* ; Herzig, S. ; Nawroth, P.P. ; Fischer, A.*

Endothelial Notch signaling controls insulin transport in muscle.

EMBO Mol. Med. 12:e09271 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ-specific manner. Insulin flux across the endothelium to muscle cells is a rate-limiting process influencing insulin-mediated lowering of blood glucose. Here, we demonstrate that Notch signaling in ECs regulates insulin transport to muscle. Notch signaling activity was higher in ECs isolated from obese mice compared to non-obese. Sustained Notch signaling in ECs lowered insulin sensitivity and increased blood glucose levels. On the contrary, EC-specific inhibition of Notch signaling increased insulin sensitivity and improved glucose tolerance and glucose uptake in muscle in a high-fat diet-induced insulin resistance model. This was associated with increased transcription of Cav1, Cav2, and Cavin1, higher number of caveolae in ECs, and insulin uptake rates, as well as increased microvessel density. These data imply that Notch signaling in the endothelium actively controls insulin sensitivity and glucose homeostasis and may therefore represent a therapeutic target for diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Caveolae ; Endothelial Cell ; Insulin Transport ; Muscle ; Notch Signaling; Diet-induced Obesity; Skeletal-muscle; Microvascular Permeability; Caveolin-1; Delivery; Capillaries; Inhibition; Expression; Mice
ISSN (print) / ISBN 1757-4676
e-ISSN 1757-4684
Journal EMBO Molecular Medicine
Quellenangaben Volume: 12, Issue: 4, Pages: , Article Number: e09271 Supplement: ,
Publisher Wiley
Publishing Place Chichester
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)