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Kreutzer, L. ; Aichler, M. ; Walch, A.K.

In situ metabolomics in cancer tissue by high-resolution mass spectrometry imaging.

In: Fundamentals and Applications of Fourier Transform Mass Spectrometry. 2019. 253-279

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This chapter introduces the in situ investigation on metabolomics in cancer tissues by high-resolution mass spectrometry imaging. Metabolomics is a rapidly increasing field, since the detection of biochemical processes can improve the diagnostic, therapeutic treatment prediction, and prognosis in diseases such as cancer. By analyzing metabolic alterations in cancer tissues, insights into the pathway regulations and the resulting clinical outcome can be obtained and associated. In recent years, especially high-resolution matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) was an emerging technique in the analysis of metabolite molecular data and their spatial distribution in tissues. The main intentions in the combination of metabolomics with MALDI MSI are the discovery of molecular biomarkers and metabolic pathways altered in tumors, as well as therapy response prediction and method development. Therefore, increasing numbers of studies were published recently, investigating the optimization of the MSI methods, overcoming the current difficulties and studying the role of clinical translation.

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