PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Deeg, C.A.* ; Hauck, S.M. ; Amann, B.* ; Kremmer, E. ; Stangassinger, M.* ; Ueffing, M.

Major retinal autoantigens remain stably expressed during all stages of spontaneous uveitis.

Mol. Immunol. 44, 3291-3296 (2007)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Equine recurrent uveitis (ERU) is a valuable model for autoimmune diseases, since it develops frequently and occurs spontaneously. We investigated the overall expression level of three major retinal autoantigens in normal retinas and various ERU stages. Analysis of retinal proteomes of both, healthy and diseased retinas revealed an almost unaffected expression of IRBP, S-antigen and cRALBP in ERU cases. Validation of these findings with western blots and immunohistochemistry confirmed constant to increased expression of these autoantigens, although loss of their physiological expression sites within retina is evident. In contrast to stable expression of autoantigens, rhodopsin, the major component of phototransduction in photoreceptors, disappeared from destructed retinas. These results explain persistent uveitic attacks even in severely damaged eyes and draw the attention to further investigations of biological pathways and regulations in autoimmune target tissues.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.768
0.937
23
33
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Uveitis; Autoimmune; Target organ; Autoantigens; Proteomics
Language
Publication Year 2007
HGF-reported in Year 2007
ISSN (print) / ISBN 0161-5890
e-ISSN 1872-9142
Journal Molecular Immunology
Quellenangaben Volume: 44, Issue: 13, Pages: 3291-3296 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Molecular Immunology (IMI)
POF-Topic(s)
Research field(s) Genetics and Epidemiology
PSP Element(s) FE 70722
G-501700-003
PubMed ID 17467057
DOI 10.1016/j.molimm.2007.02.027
WOS ID 000247272200003
Scopus ID 34247898996
Erfassungsdatum 2007-07-11
[➜Report correction]