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Discerning calvarian microvascular networks by combined optoacoustic ultrasound microscopy.
Photoacoustics 19:100178 (2020)
Bone microvasculature plays a paramount role in bone marrow maintenance, development, and hematopoiesis. Studies of calvarian vascular patterns within living mammalian skull with the available intravital microscopy techniques are limited to small scale observations. We developed an optical-resolution optoacoustic microscopy method combined with ultrasound biomicroscopy in order to reveal and discern the intricate networks of calvarian and cerebral vasculature over large fields of view covering majority of the murine calvaria. The vasculature segmentation method is based on an angle-corrected homogeneous model of the rodent skull, generated using simultaneously acquired three-dimensional pulse-echo ultrasound images. The hybrid microscopy design along with the appropriate skull segmentation method enable high throughput studies of a living bone while facilitating correct anatomical interpretation of the vasculature images acquired with optical resolution optoacoustic microscopy.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Optoacoustic Microscopy ; Photoacoustic Microscopy ; Ultrasound Biomicroscopy ; Murine Calvaria ; Bone Vasculature ; Vasculature Segmentation; Photoacoustic Microscopy; Bone-marrow; Brain
ISSN (print) / ISBN
2213-5979
Journal
Photoacoustics
Quellenangaben
Volume: 19,
Article Number: 100178
Publisher
Elsevier
Publishing Place
Hackerbrucke 6, 80335 Munich, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
European Research Council