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Subliminal fatty acid-induced gut-brain signals attenuate sensitivity to exteroceptive rewards in food but not in sex or financial domains, in healthy men.
Physiol. Behav. 219:112861 (2020)
Background Reward sensitivity can generalize across domains, but evidence for generalization of suppressive reward-related stimulation is sparse, especially in the context of interoceptive nutrient-related stimuli. We hypothesized that subliminal fatty acid-induced gut-brain signals could attenuate sensitivity to exteroceptive rewards, not only within the food domain but also across domains.Method Intragastric infusion of 2.5 g lauric acid (fat condition) or saline (saline condition) was administered to 59 healthy heterosexual male volunteers in a blinded fashion. To assess whether the resulting interoceptive signals attenuate reward sensitivity within the food domain, participants rated the palatability of food images and performed a progressive ratio task. To assess whether such attenuation effect generalizes to the sexual and financial reward domains, participants rated attractiveness of female face images and performed an intertemporal monetary choice task.Results Participants' ratings of food images were lower (F-1,F-172 = 4.51, p = 0.035, Cohen's d: -0.20) in the fat condition. The progressive ratio task terminated earlier in the fat condition compared to saline (F-1,F-52 = 4.17, p = 0.046, odds ratio = 0.31, 95%CI [0.11, 0.98]). Participants' ratings of female face images did not differ between conditions (F-1,F-172= 1.85, p= 0.19, Cohen's d: -0.15). Moreover, the monetary discounting rate did not differ significantly between conditions.Conclusion Overall, these findings suggest a domain-specific effect of subliminal fatty acid infusion on decreasing reward sensitivity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Homeostatic & Hedonic ; Gut-brain Axis ; Generalized Reward Sensitivity ; Food Images ; Interoceptive Gut Signals; Sensory-specific Satiety; Obesity
ISSN (print) / ISBN
0031-9384
e-ISSN
1873-507X
Journal
Physiology & Behavior
Quellenangaben
Volume: 219,
Article Number: 112861
Publisher
Elsevier
Publishing Place
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Non-patent literature
Publications
Reviewing status
Peer reviewed