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Murine Gammaherpesvirus 68 Contains Two Functional Lytic Origins of Replication.
J. Virol. 81, 7300-7305 (2007)
Publ. Version/Full Text Volltext
DOI
PMC
A 1.25-kbp DNA fragment from the right side of the genome containing the lytic origin of replication (oriLyt) of murine gammaherpesvirus 68 (MHV-68) has been identified by a plasmid replication assay. Here we show that a mutant MHV-68 with a deletion of an essential part of this oriLyt, generated by using an MHV-68 bacterial artificial chromosome, was only slightly attenuated and still able to replicate but that a mutant containing an additional deletion on the left side of the genome was replication deficient. The newly identified region was sufficient to support plasmid replication, thus providing evidence for a second oriLyt.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0022-538X
e-ISSN
1098-5514
Journal
Journal of Virology
Quellenangaben
Volume: 81,
Issue: 13,
Pages: 7300-7305
Publisher
American Society for Microbiology (ASM)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Hematopoetic Cell Transplants (IMI-KHZ)