PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Wang, X.* ; Lou, N.* ; Eberhardt, A.* ; Yang, Y.* ; Kusk, P.* ; Xu, Q.* ; Förstera, B. ; Peng, S.* ; Shi, M.* ; Ladrón-de-Guevara, A.* ; Delle, C.* ; Sigurdsson, B.* ; Xavier, A.L.R.* ; Ertürk, A. ; Libby, R.T.* ; Chen, L.* ; Thrane, A.S.* ; Nedergaard, M.*

An ocular glymphatic clearance system removes beta-amyloid from the rodent eye.

Sci. Transl. Med. 12:eaaw3210 (2020)
Postprint DOI PMC
Open Access Green
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. beta-amyloid (A beta) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal A beta was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced efflux, whereas atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, A. leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The results suggest that, in rodents, the removal of fluid and metabolites from the intraocular space occurs through a glymphatic pathway that might be impaired in glaucoma.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
16.304
3.022
43
52
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Optic-nerve Head; Ganglion-cell Degeneration; Intraocular-pressure; Mouse Model; Intracranial-pressure; Lamina-cribrosa; Disc Edema; Glaucoma; Brain; Fluid
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 1946-6234
e-ISSN 1946-6242
Journal Science Translational Medicine
Quellenangaben Volume: 12, Issue: 536, Pages: , Article Number: eaaw3210 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status Peer reviewed
Institute(s) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505800-001
DOI 10.1126/scitranslmed.aaw3210
WOS ID WOS:000521830800001
Scopus ID 85082463850
PubMed ID 32213628
Erfassungsdatum 2020-04-02
[➜Report correction]