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Hadrup, N.* ; Zhernovkov, V.* ; Jacobsen, N.R.* ; Voss, C. ; Strunz, M. ; Schiller, H. B. ; Halappanavar, S.* ; Poulsen, S.S.* ; Kholodenko, B.* ; Stöger, T. ; Saber, A.T.* ; Vogel, U.*

Acute phase response as a biological mechanism-of-action of (nano)particle-induced cardiovascular disease.

Small 16:1907476 (2020)
Publ. Version/Full Text DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particle-induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle-induced acute phase response provides a means for risk assessment of particle-induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
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Publication type Article: Journal article
Document type Review
Keywords Atherosclerosis ; Cardiovascular Diseases ; C-reactive Protein ; Nanoparticles ; Occupational Exposure ; Serum Amyloid A; Particulate Air-pollution; C-reactive Protein; Titanium-dioxide Nanoparticles; Reverse Cholesterol Transport; Long-term Exposure; Serum Amyloid-a; Welding Fumes; Physicochemical Properties; Pulmonary Exposure; In-vivo
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 1613-6810
e-ISSN 1613-6829
Journal Small
Quellenangaben Volume: 16, Issue: 21, Pages: , Article Number: 1907476 Supplement: ,
Publisher Wiley
Publishing Place Postfach 101161, 69451 Weinheim, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
German Center for Lung Research (DZL)
POF-Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Research field(s) Lung Research
PSP Element(s) G-505000-001
G-501800-810
DOI 10.1002/smll.201907476
WOS ID WOS:000522067300001
Scopus ID 85082447115
Erfassungsdatum 2020-04-07
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