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Kollmus, H.* ; Fuchs, H. ; Lengger, C. ; Haselimashhadi, H.* ; Bogue, M.A.* ; Östereicher, M.A. ; Horsch, M. ; Adler, T. ; Aguilar-Pimentel, J.A. ; Amarie, O.V. ; Becker, L. ; Beckers, J. ; Calzada-Wack, J. ; Garrett, L. ; Hans, W. ; Hölter, S.M. ; Klein-Rodewald, T. ; Maier, H. ; Mayer-Kuckuk, P. ; Miller, G. ; Moreth, K. ; Neff, F. ; Rathkolb, B. ; Rácz, I. ; Rozman, J. ; Spielmann, N. ; Treise, I. ; Busch, D.H. ; Graw, J. ; Klopstock, T.* ; Wolf, E.* ; Wurst, W. ; Yildirim, A.Ö. ; Mason, J.* ; Torres, A.* ; Balling, R.* ; Mehaan, T.* ; Gailus-Durner, V. ; Schughart, K.* ; Hrabě de Angelis, M.

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.

Mamm. Genome 31, 30-48 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Journal Mammalian Genome
Quellenangaben Volume: 31, Issue: 1-2, Pages: 30-48 Article Number: , Supplement: ,
Publisher Springer
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
Institute of Lung Biology (LHI)