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Open Access Green as soon as Postprint is submitted to ZB.
A genome-wide linkage scan for 25-OH-D3 and 1,25-(OH)2-D3 serum levels in asthma families.
J. Steroid Biochem. Mol. Biol. 103, 799-802 (2007)
To identify genome regions linked to serum vitamin D metabolites we analyzed 25-OH-D3 and 1,25-(OH)2-D3 levels from 947 participants of a family study recruited for asthma.From these individuals data were available from a previous genome scan that included 364 autosomal microsatellite marker. 25-OH-D3 levels showed a heritability of 80% in these families while 1,25-(OH)2-D3 reached only 30%. Genome-wide linkage using variance component analysis showed increased LOD scores for 25-OH-D3 at marker D1S2815 (unadjusted LOD 2.9), D2S2153 (LOD 3.4), D5S2017 (LOD 2.5), D6S260 (LOD 2.1) and D17S1824 (2.5). In contrast, the maximum LOD score for 1,25-(OH)2-D3 level was only 1.2 at marker D17S926.We conclude that only 25-OH-D3 serum levels are under genetic control where several genes are involved. The lead linkage region does not code for enzymes already known in the metabolic pathway of vitamin D and may therefore contain further genes relevant to the regulation of vitamin D serum levels.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Calcidiol; Calcitriol; Genome scan; CYP26B1; TGFA
ISSN (print) / ISBN
0960-0760
e-ISSN
0960-0760
Quellenangaben
Volume: 103,
Issue: 3-5,
Pages: 799-802
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)