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Baum, P.* ; Paeschke, S.* ; Klöting, N. ; Blüher, M.* ; Kern, M.* ; Serke, H.* ; Nowicki, M.* ; Kosacka, J.*

COMP-ang-1 improves glucose uptake in db/db mice with type 2 diabetes.

Horm. Metab. Res. 52, 685-688 (2020)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in ob / ob mice. However, the mechanism of the antidiabetic effect of COMP-Ang-1 is completely unknown. Therefore, we elucidated the diabetes protective molecular mechanisms of COMP-Ang-1 in diabetic db / db mouse model. COMP-Ang-1 (0.5ng/g body weight) or aqueous NaCl solution was injected intraperitoneally per day in 21 consecutive days into 3-month old, male db / db mice (n=10 per group). Blood glucose and HbA1c levels were determined at baseline and 21 days after COMP-Ang-1 or NaCl treatment. The effect of COMP-Ang-1 on glucose uptake was investigated by euglycemic-hyperinsulinemic clamp studies and key genes of glucose metabolism were studied by Western blot analysis. Our findings indicate that COMP-Ang-1 improves glucose metabolism in a tissue specific manner by regulating HIF-1 alpha transcriptional genes of GLUT-1 expression.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Comp-ang-1 ; Hif-1 Alpha Glucose Uptake ; Type 2 Diabetes ; Db ; Dbmice; Db/db Mice
ISSN (print) / ISBN 0018-5043
e-ISSN 1439-4286
Journal Hormone and Metabolic Research
Quellenangaben Volume: 52, Issue: 9, Pages: 685-688 Article Number: , Supplement: ,
Publisher Thieme
Publishing Place Rudigerstr 14, D-70469 Stuttgart, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants SFB1052/2 B04 (to NK)
368/03/15, 93400-989 (to JK)