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Open Access Green as soon as Postprint is submitted to ZB.
COMP-ang-1 improves glucose uptake in db/db mice with type 2 diabetes.
Horm. Metab. Res. 52, 685-688 (2020)
Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in ob / ob mice. However, the mechanism of the antidiabetic effect of COMP-Ang-1 is completely unknown. Therefore, we elucidated the diabetes protective molecular mechanisms of COMP-Ang-1 in diabetic db / db mouse model. COMP-Ang-1 (0.5ng/g body weight) or aqueous NaCl solution was injected intraperitoneally per day in 21 consecutive days into 3-month old, male db / db mice (n=10 per group). Blood glucose and HbA1c levels were determined at baseline and 21 days after COMP-Ang-1 or NaCl treatment. The effect of COMP-Ang-1 on glucose uptake was investigated by euglycemic-hyperinsulinemic clamp studies and key genes of glucose metabolism were studied by Western blot analysis. Our findings indicate that COMP-Ang-1 improves glucose metabolism in a tissue specific manner by regulating HIF-1 alpha transcriptional genes of GLUT-1 expression.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Comp-ang-1 ; Hif-1 Alpha Glucose Uptake ; Type 2 Diabetes ; Db ; Dbmice; Db/db Mice
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
0018-5043
e-ISSN
1439-4286
Journal
Hormone and Metabolic Research
Quellenangaben
Volume: 52,
Issue: 9,
Pages: 685-688
Publisher
Thieme
Publishing Place
Rudigerstr 14, D-70469 Stuttgart, Germany
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-506500-001
Grants
SFB1052/2 B04 (to NK)
368/03/15, 93400-989 (to JK)
368/03/15, 93400-989 (to JK)
WOS ID
WOS:000568875600009
Scopus ID
85090816250
PubMed ID
32252105
Erfassungsdatum
2020-04-21