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Otto, L.* ; Budde, K.* ; Kastenmüller, G. ; Kaul, A.* ; Völker, U.* ; Völzke, H.* ; Adamski, J. ; Kühn, J.P.* ; Krumsiek, J. ; Artati, A. ; Nauck, M.* ; Friedrich, N.* ; Pietzner, M.*

Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population.

Sci. Rep. 10:1487 (2020)

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Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher VAT or SAT amount among subjects free of metabolic diseases to identify possible contributing metabolic pathways. The study population comprised 491 subjects [mean (standard deviation): age 44.6yrs (13.0), body mass index 25.4kg/m(2) (3.6), 60.1% females] without diabetes, hypertension, dyslipidemia, the metabolic syndrome or impaired renal function. We associated MRI-derived fat amounts with mass spectrometry-derived metabolites in plasma and urine using linear regression models adjusting for major confounders. We tested for sex-specific effects using interactions terms and performed sensitivity analyses for the influence of insulin resistance on the results. VAT and SAT were significantly associated with 155 (101 urine) and 49 (29 urine) metabolites, respectively, of which 45 (27 urine) were common to both. Major metabolic pathways were branched-chain amino acid metabolism (partially independent of insulin resistance), surrogate markers of oxidative stress and gut microbial diversity, and cortisol metabolism. We observed a novel positive association between VAT and plasma levels of the potential pharmacological agent piperine. Sex-specific effects were only a few, e.g. the female-specific association between VAT and O-methylascorbate. In brief, higher VAT was associated with an unfavorable metabolite profile in a sample of healthy, mostly non-obese individuals from the general population and only few sex-specific associations became apparent.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Visceral Fat; Metabolite Profiles; Insulin-resistance; Black Pepper; Amino-acids; Obesity; Blood; Metabolomics; Mortality; Piperine

ISSN (print) / ISBN 2045-2322

e-ISSN 2045-2322

Journal Scientific Reports

Quellenangaben Volume: 10, Issue: 1, Article Number: 1487

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Experimental Genetics (IEG)
Institute of Computational Biology (ICB)
CF Metabolomics & Proteomics (CF-MPC)
Molekulare Endokrinologie und Metabolismus (MEM)