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Cohrs, C.M. ; Panzer, J.K. ; Drotar, D.M. ; Enos, S.J. ; Kipke, N. ; Chen, C. ; Schöniger, E. ; Ehehalt, F.* ; Distler, M.* ; Brennand, A.* ; Bornstein, S.R. ; Weitz, J. ; Solimena, M. ; Speier, S.

Dysfunction of persisting β cells is a key feature of early type 2 diabetes pathogenesis.

Cell Rep. 31:107469 (2020)
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Open Access Gold
Creative Commons Lizenzvertrag
Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet beta cells. However, the role and sequence of b cell dysfunction and mass loss for reduced insulin levels in type 2 diabetes pathogenesis are unclear. Here, we exploit freshly explanted pancreas specimens from metabolically phenotyped surgical patients using an in situ tissue slice technology. This approach allows assessment of beta cell volume and function within pancreas samples of metabolically stratified individuals. We show that, in tissue of pre-diabetic, impaired glucose-tolerant subjects, beta cell volume is unchanged, but function significantly deteriorates, exhibiting increased basal release and loss of first-phase insulin secretion. In individuals with type 2 diabetes, function within the sustained beta cell volume further declines. These results indicate that dysfunction of persisting beta cells is a key factor in the early development and progression of type 2 diabetes, representing a major target for diabetes prevention and therapy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Beta Cell Function ; Beta Cell Mass ; Human Pancreas ; Insulin Secretion ; Type 2 Diabetes; Impaired Glucose-tolerance; Insulin-resistance; In-situ; Mass; Islet; Mechanisms; Pancreas; Risk; Secretion; Turnover
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 31, Issue: 1, Pages: , Article Number: 107469 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-005
G-502600-001
DOI 10.1016/j.celrep.2020.03.033
WOS ID WOS:000524976500006
Scopus ID 85082749972
Erfassungsdatum 2020-05-04
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