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NNT in NSCLC: No need to worry?
J. Exp. Med. 217:e20200310 (2020)
In this study, Ward et al. (https://doi.org/10.1084/jem.20191689) provide exciting evidence that nucleotide nicotinamide transhydrogenase (NNT), a mitochondrial matrix-located enzyme harnessing the proton gradient to generate NADPH using NADH, markedly contributes to non-small cell lung carcinoma (NSCLC), which is abrogated in the murine C57BL/6J background, a strain known to be deficient in NNT.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Thioredoxin Reductase; Embryogenesis
ISSN (print) / ISBN
0022-1007
e-ISSN
1540-9538
Journal
Journal of Experimental Medicine
Quellenangaben
Volume: 217,
Issue: 6,
Article Number: e20200310
Publisher
Rockefeller University Press
Publishing Place
950 Third Ave, 2nd Flr, New York, Ny 10022 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Metabolism and Cell Death (MCD)