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Kullmann, S. ; Valenta, V. ; Wagner, R. ; Tschritter, O.* ; Machann, J. ; Häring, H.-U. ; Fritsche, A. ; Heni, M. ; Preissl, H.

Brain insulin sensitivity is linked to adiposity and body fat distribution.

Nat. Commun. 11:1841 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Brain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain insulin resistant. How brain insulin responsiveness affects long-term weight and body fat composition in humans is still unknown. Here we show that high brain insulin sensitivity before lifestyle intervention associates with a more pronounced reduction in total and visceral fat during the program. High brain insulin sensitivity is also associated with less regain of fat mass during a nine year follow-up. Cross-sectionally, strong insulin responsiveness of the hypothalamus associates with less visceral fat, while subcutaneous fat is unrelated. Our results demonstrate that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and associates with a favorable body fat distribution. Since visceral fat is strongly linked to diabetes, cardiovascular risk and cancer, these findings have implications beyond metabolic diseases and indicate the necessity of strategies to resolve brain insulin resistance.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Endogenous Glucose-production; Life-style Intervention; Intranasal Insulin; Tissue; Overweight; Hyperinsulinemia; Metabolism; Phenotypes; Resistance; Receptor
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 11, Issue: 1, Pages: , Article Number: 1841 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
DOI 10.1038/s41467-020-15686-y
WOS ID WOS:000564285200006
Scopus ID 85083477573
PubMed ID 32296068
Erfassungsdatum 2020-04-22
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