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Open Access Green as soon as Postprint is submitted to ZB.
The proteasome system in health and disease.
Adv. Exp. Med. Biol. 1233, 55-100 (2020)
The proteasome is involved in the regulation of all cellular pathways and consequently plays a central role in the control of cellular homeostasis. Together with its regulators, it is at the frontline, both as an actor and as a target, in human health and when homeostasis is disturbed in disease. In this review, we aim to provide an overview of the many levels at which the functions of the proteasome and its regulators can be regulated to cope with cellular needs or are altered in pathological conditions.
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Publication type
Article: Journal article
Document type
Review
Keywords
19s Complex ; Disease ; Pa200 ; Pa28 ; Pi31 ; Proteasome; Activator Reg-gamma; Multicatalytic Proteinase Complex; Endoplasmic-reticulum Stress; 26 S-proteasome; 20s Proteasome; Oxidative-stress; Cell-cycle; Nuclear Proteasome; Interferon-gamma; Cigarette-smoke
ISSN (print) / ISBN
0065-2598
Book Volume Title
Proteostasis and Disease
Quellenangaben
Volume: 1233,
Pages: 55-100
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)