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Lasch, F.* ; Karch, A.* ; Koch, A.* ; Derlin, T.* ; Voskrebenzev, A.* ; Alsady, T.M.* ; Hoeper, M.M.* ; Gall, H.* ; Roller, F.* ; Harth, S.* ; Steiner, D.* ; Krombach, G.* ; Ghofrani, H.A.* ; Rengier, F.* ; Heußel, C.P.* ; Grünig, E.* ; Beitzke, D.* ; Hacker, M.* ; Lang, I.M.* ; Behr, J. ; Bartenstein, P.* ; Dinkel, J. ; Schmidt, K.H.* ; Kreitner, K.F.* ; Frauenfelder, T.* ; Ulrich, S.* ; Hamer, O.W.* ; Pfeifer, M.* ; Johns, C.S.* ; Kiely, D.G.* ; Swift, A.J.* ; Wild, J.* ; Vogel-Claussen, J.*

Comparison of MRI and VQ-SPECT as a screening test for patients with suspected CTEPH: CHANGE-MRI study design and rationale.

Front. Cardiovasc. Med. 7:51 (2020)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The diagnostic strategy for chronic thromboembolic pulmonary hypertension (CTEPH) is composed of two components required for a diagnosis of CTEPH: the presence of chronic pulmonary embolism and an elevated pulmonary artery pressure. The current guidelines require that ventilation-perfusion single-photon emission computed tomography (VQ-SPECT) is used for the first step diagnosis of chronic pulmonary embolism. However, VQ-SPECT exposes patients to ionizing radiation in a radiation sensitive population. The prospective, multicenter, comparative phase III diagnostic trial CTEPH diagnosis Europe - MRI (CHANGE-MRI, identifier NCT02791282) aims to demonstrate whether functional lung MRI can serve as an equal rights alternative to VQ-SPECT in a diagnostic strategy for patients with suspected CTEPH. Positive findings are verified with catheter pulmonary angiography or computed tomography pulmonary angiography (gold standard). For comparing the imaging methods, a co-primary endpoint is used. (i) the proportion of patients with positive MRI in the group of patients who have a positive SPECT and gold standard diagnosis for chronic pulmonary embolism and (ii) the proportion of patients with positive MRI in the group of patients with negative SPECT and gold standard. The CHANGE-MRI trial will also investigate the performance of functional lung MRI without i.v. contrast agent as an index test and identify cardiac, hemodynamic, and pulmonary MRI-derived parameters to estimate pulmonary artery pressures and predict 6-12 month survival. Ultimately, this study will provide the necessary evidence for the discussion about changes in the recommendations on the diagnostic approach to CTEPH.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Mri ; Vq-spect ; Cteph ; Ph ; Pulmonary Embolism ; Diagnostic Strategy; Magnetic-resonance Angiography; Pulmonary-embolism; Ventilation; Diagnosis; Bias
ISSN (print) / ISBN 2297-055X
e-ISSN 2297-055X
Journal Frontiers in Cardiovascular Medicine
Quellenangaben Volume: 7, Issue: , Pages: , Article Number: 51 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Lung Health and Immunity (LHI)