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Kumar, V.* ; Agrawal, R.* ; Pandey, A.* ; Kopf, S.* ; Hoeffgen, M.* ; Kaymak, S.* ; Bandapalli, O.R.* ; Gorbunova, V.* ; Seluanov, A.* ; Mall, M.A.* ; Herzig, S. ; Nawroth, P.P.

Compromised DNA repair is responsible for diabetes-associated fibrosis.

EMBO J. 39:e103477 (2020)
Publ. Version/Full Text DOI PMC
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Diabetes-associated organ fibrosis, marked by elevated cellular senescence, is a growing health concern. Intriguingly, the mechanism underlying this association remained unknown. Moreover, insulin alone can neither reverse organ fibrosis nor the associated secretory phenotype, favoring the exciting notion that thus far unknown mechanisms must be operative. Here, we show that experimental type 1 and type 2 diabetes impairs DNA repair, leading to senescence, inflammatory phenotypes, and ultimately fibrosis. Carbohydrates were found to trigger this cascade by decreasing the NAD(+)/NADH ratio and NHEJ-repair in vitro and in diabetes mouse models. Restoring DNA repair by nuclear over-expression of phosphomimetic RAGE reduces DNA damage, inflammation, and fibrosis, thereby restoring organ function. Our study provides a novel conceptual framework for understanding diabetic fibrosis on the basis of persistent DNA damage signaling and points to unprecedented approaches to restore DNA repair capacity for resolution of fibrosis in patients with diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Diabetes ; Dna Double-strand Breaks ; Nuclear Isoform Of The Receptor For Advanced Glycation End Products ; Pulmonary Fibrosis ; Reducing Carbohydrates; Glycation End-products; Redox-optimized Ros; Cellular Senescence; Pulmonary-fibrosis; Beta-galactosidase; Telomerase Mutations; Premature Senescence; Monogenic Diseases; Oxidative Stress; Oxygen-tension
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Journal EMBO Journal, The
Quellenangaben Volume: 39, Issue: 11, Pages: , Article Number: e103477 Supplement: ,
Publisher Wiley
Publishing Place Heidelberg, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-251
DOI 10.15252/embj.2019103477
WOS ID WOS:000528710600001
Scopus ID 85084158612
PubMed ID 32338774
WOS ID WOS:000539233000003
Erfassungsdatum 2020-04-30
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