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Sungnak, W.* ; Huang, N.* ; Bécavin, C.* ; Berg, M.* ; Queen, R.* ; Litvinukova, M.* ; Talavera-López, C.* ; Maatz, H.* ; Reichart, D.* ; Sampaziotis, F.* ; Worlock, K.B.* ; Yoshida, M.* ; Barnes, J.L.* ; HCA Lung Biological Network (Schiller, H. B. ; Theis, F.J.)

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.

Nat. Med. 26, 681–687 (2020)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1078-8956
e-ISSN 1546-170X
Journal Nature medicine
Quellenangaben Volume: 26, Issue: , Pages: 681–687 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Lung Health and Immunity (LHI)
Institute of Computational Biology (ICB)