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Role of exosomal microRNAs in lung cancer biology and clinical applications.
Cell Prolif. 53:e12828 (2020)
Exosomes, small extracellular vesicles ranging from 30 to 150 nm, are secreted by various cell types, including tumour cells. Recently, microRNAs (miRNAs) were identified to be encapsulated and hence protected from degradation within exosomes. These exosomal miRNAs can be horizontally transferred to target cells, in which they subsequently modulate biological processes. Increasing evidence indicates that exosomal miRNAs play a critical role in modifying the microenvironment of lung cancers, possibly facilitating progression, invasion, angiogenesis, metastasis and drug resistance. In this review, we summarize the novel findings on exosomal miRNA functions during lung cancer initiation and progression. In addition, we highlight their potential role and challenges as biomarkers in lung cancer diagnosis, prognosis and drug resistance and as therapeutic agents.
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Publication type
Article: Journal article
Document type
Review
Keywords
Biomarker ; Exosomal Mirnas ; Exosomes ; Lung Cancer ; Therapy; Epithelial-mesenchymal Transition; Extracellular Vesicles; Cells; Mirna; Cargo; Communication; Expression; Cisplatin; Plasma; Microvesicles
ISSN (print) / ISBN
0008-8730
e-ISSN
1365-2184
Journal
Cell Proliferation
Quellenangaben
Volume: 53,
Issue: 6,
Article Number: e12828
Publisher
Blackwell
Publishing Place
Oxford [u.a.] ; Berlin ; Vienna
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)