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Rödel, F.* ; Arenas, M.* ; Ott, O.J.* ; Fournier, C.* ; Georgakilas, A.G.* ; Tapio, S. ; Trott, K.R.* ; Gaipl, U.S.*

Low-dose radiation therapy for COVID-19 pneumopathy: What is the evidence?

Strahlenther. Onkol. 196, 679-682 (2020)
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In the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 & x202f;Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 & x202f;Gy. This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation.
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Publication type Article: Journal article
Document type Review
Keywords Sars-cov-2 ; Low-dose Radiation Therapy ; Pneumonia ; Covid-19 ; Anti-inflammatory; Radiotherapy; Induction; Repair
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0179-7158
e-ISSN 1439-099X
Journal Strahlentherapie und Onkologie : Journal of Radiation Oncology, Biology, Physics
Quellenangaben Volume: 196, Issue: 8, Pages: 679-682 Article Number: , Supplement: ,
Publisher Urban & Vogel
Publishing Place Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Radiation Sciences
PSP Element(s) G-500200-001
DOI 10.1007/s00066-020-01635-7
WOS ID WOS:000531199700001
Scopus ID 85084477442
PubMed ID 32388805
Erfassungsdatum 2020-05-20
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