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Anti-inflammatory glucocorticoid action: Genomic insights and emerging concepts.
Curr. Opin. Pharmacol. 53, 35-44 (2020)
Glucocorticoids (GCs) are widely used immunomodulators. They regulate gene expression by binding and activating the Glucocorticoid Receptor (GR), but underlying transcriptional mechanisms remain enigmatic. This review summarizes recent findings identifyingspecific GR-bound DNA sequences whose configuration may affect transcriptional output. Additional factors affecting GR's anti-inflammatory actions, including different chromatin states such as DNAse hypersensitive regions and histone marks will be discussed, together with the relevant transcriptional co-regulators and promoter/enhancer features. Furthermore, the involvement of non-coding RNAs such as lncRNAs, miRNAs and eRNAs adds another level of regulation to the GR's transcriptional activity. Characterizing and understanding these multiple mechanisms will be crucial for developing more targeted immunomodulatory therapies with reduced adverse effects such as obesity, diabetes and osteoporosis.
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4.807
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Publication type
Article: Journal article
Document type
Review
Keywords
Dna-binding; Chromatin Accessibility; Receptor Structure; Nuclear Receptors; Kappa-b; Transcription; Repression; Gr; Activation; Mechanisms
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
1471-4892
e-ISSN
1471-4973
Journal
Current opinion in pharmacology
Quellenangaben
Volume: 53,
Pages: 35-44
Publisher
Elsevier
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
POF-Topic(s)
90000 - German Center for Diabetes Research
30201 - Metabolic Health
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-501900-227
G-502595-001
G-502595-001
Grants
Entzuendungsprozesse
DFG
ERC
DFG
ERC
WOS ID
WOS:000591504200006
Scopus ID
85084382153
PubMed ID
32416533
Erfassungsdatum
2020-05-20