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Antò, J.M.* ; Sunyer, J.* ; Basagana, X.* ; García-Esteban, R.* ; Cerveri, I.* ; de Marco, R.* ; Heinrich, J. ; Janson, C.* ; Jarvis, D.* ; Kogevinas, M.* ; Kuenzli, N.* ; Leynaert, B.* ; Svanes, C.* ; Wjst, M. ; Gislason, T.* ; Burney, P.*

Risk factors of new-onset asthma in adults: A population-based international cohort study.

Allergy 65, 1021-1030 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: The occurrence of new-onset asthma during adulthood is common, but there is insufficient understanding of its determinants including the role of atopy. OBJECTIVE: To assess the risk factors for the development of new-onset asthma in middle-aged adults and to compare them according to atopy. METHODS: A longitudinal analysis of 9175 young adults who participated in two surveys of the European Community Respiratory Health Survey (ECRHS) conducted 9 years apart. FINDINGS: We observed 179 cases of new-onset asthma among 4588 participants who were free of asthma and reported at the beginning of the follow-up that they had never had asthma (4.5 per 1000 person-years). In a logistic regression, the following risk factors were found to increase the risk of new-onset asthma: female gender (OR: 1.97; 95% confidence interval (CI): 1.38, 2.81), bronchial hyperresponsiveness (3.25; 2.19, 4.83), atopy (1.55; 1.08, 2.21), FEV(1) < 100 % predicted (1.87; 1.34, 2.62), nasal allergy (1.98;1.39,2.84) and maternal asthma (1.91; 1.13; 3.21). Obesity, respiratory infections in early life and high-risk occupations increased the risk of new-onset asthma although we had limited power to confirm their role. Among the atopics, total IgE and sensitization to cat were independently related to the risk of new-onset asthma. The proportion of new-onset asthma attributable to atopy varied from 12% to 21%. CONCLUSION: Adults reporting that they had never had asthma were at a substantial risk of new-onset asthma as a result of multiple independent risk factors including lung function. Atopy explains a small proportion of new-onset adult asthma.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Asthma; Atopy; Bronchial Hyperresponsiveness; ECRHS; Environment; Lung function; Respiratory symptoms
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 65, Issue: 8, Pages: 1021-1030 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Lung Health and Immunity (LHI)