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Consequences of obesity on the sense of taste: Taste buds as treatment targets?
Diabetes Metab. J. 44, 509-528 (2020)
Premature obesity-related mortality is caused by cardiovascular and pulmonary diseases, type 2 diabetes mellitus, physical disabilities, osteoarthritis, and certain types of cancer. Obesity is caused by a positive energy balance due to hyper-caloric nutrition, low physical activity, and energy expenditure. Overeating is partially driven by impaired homeostatic feedback of the peripheral energy status in obesity. However, food with its different qualities is a key driver for the reward driven hedonic feeding with tremendous consequences on calorie consumption. In addition to visual and olfactory cues, taste buds of the oral cavity process the earliest signals which affect the regulation of food intake, appetite and satiety. Therefore, taste buds may play a crucial role how food related signals are transmitted to the brain, particularly in priming the body for digestion during the cephalic phase. Indeed, obesity development is associated with a significant reduction in taste buds. Impaired taste bud sensitivity may play a causal role in the pathophysiology of obesity in children and adolescents. In addition, genetic variation in taste receptors has been linked to body weight regulation. This review discusses the importance of taste buds as contributing factors in the development of obesity and how obesity may affect the sense of taste, alterations in food preferences and eating behavior.
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Publication type
Article: Journal article
Document type
Review
Keywords
Dysgeusia ; Feeding Behavior ; Food Preferences ; Obesity ; Taste ; Taste Buds ; Taste Perception; Y Gastric Bypass; Sweet Taste; Cell Communication; Bariatric Surgery; Morbidly Obese; Gene Tas2r38; Weight-loss; Receptor; Fat; Sensitivity
ISSN (print) / ISBN
2233-6079
e-ISSN
2233-6087
Journal
Diabetes & Metabolism Journal
Quellenangaben
Volume: 44,
Issue: 4,
Pages: 509-528
Publisher
Korean Diabetes Association
Publishing Place
Seoul, South Korea
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)