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Elhadad, M.A. ; Karavasiloglou, N.* ; Wulaningsih, W.* ; Tsilidis, K.K.* ; Tzoulaki, I.* ; Patel, C.J.* ; Rohrmann, S.*

Metabolites, nutrients, and lifestyle factors in relation to coffee consumption: An environment-wide association study.

Nutrients 12:1470 (2020)

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	Open Access Gold

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Coffee consumption has been inversely associated with various diseases; however, the underlying mechanisms are not entirely clear. We used data of 17,752 Third National Health and Nutrition Examination Survey participants to investigate the association of 245 metabolites, nutrients, and lifestyle factors with coffee consumption. We used data from the first phase (n= 8825) to identify factors with a false discovery rate of <5%. We then replicated our results using data from the second phase (n= 8927). Regular coffee consumption was positively associated with active and passive smoking, serum lead and urinary cadmium concentrations, dietary intake of potassium and magnesium, and aspirin intake. In contrast, regular coffee consumption was inversely associated with serum folate and red blood cell folate levels, serum vitamin E and C, and beta-cryptoxanthin concentrations, Healthy Eating Index score, and total serum bilirubin. Most of the aforementioned associations were also observed for caffeinated beverage intake. In our assessment of the association between coffee consumption and selected metabolites, nutrients, and lifestyle factors, we observed that regular coffee and caffeinated beverage consumption was strongly associated with smoking, serum lead levels, and poorer dietary habits.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Coffee Consumption ; Environment Wide Association Study ; Metabolites ; Nutrients ; Lifestyle ; National Health And Nutrition Examination Survey (nhanes); Decaffeinated Coffee; Caffeine Intake; Cancer Risk; Metaanalysis; Tea; Health; Biomarkers; Increases; Mortality; Drinking

ISSN (print) / ISBN 2072-6643

e-ISSN 2072-6643

Journal Nutrients

Quellenangaben Volume: 12, Issue: 5, Article Number: 1470

Publisher MDPI

Publishing Place Basel

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)