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Sagan, D. ; Eckardt-Schupp, F. ; Eicholtz-Wirth, H.

Reduced expression of SRC family kinases decreases PI3K activity in NBS1-/- lymphoblasts.

Biochem. Biophys. Res. Commun. 377, 181-186 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
SRC family kinases (SFKs) are involved in the activation of phosphatidylinositol-3-kinase (PI3K). In addition, the activity of this lipid kinase can be regulated by the DNA repair protein NBS1. Here, we describe a disturbed expression of some members of the non-receptor tyrosine kinase family in lymphoblastoid cell lines generated from cells of Nijmegen breakage syndrome (NBS) patients. Especially, only minor amounts of the kinases LCK and HCK are expressed in the NBS1(-/-) cell lines as compared to the consanguineous NBS1(+/-) cells. We demonstrate that SFK activity is important for a proper activation of PI3K in these cells and that it is reduced in NBS1(-/-) cells. We provide evidence that the observed reduced PI3K activity in NBS lymphoblasts is caused by an impaired expression of the SFKs LCK and/or HCK. Thus, our data establish a new function for the NBS1 protein as a regulator of PI3K activity via SFK members.
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Publication type Article: Journal article
Document type Scientific Article
Keywords PI3K; NBS1; SFK; LCK; HCK
Language english
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 0006-291X
e-ISSN 1090-2104
Journal Biochemical and Biophysical Research Communications
Quellenangaben Volume: 377, Issue: 1, Pages: 181-186 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
PSP Element(s) G-500200-002
DOI 10.1016/j.bbrc.2008.09.098
Scopus ID 54449100623
Erfassungsdatum 2008-12-08
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