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Shedding light on the venom proteomes of the allergy-relevant Hymenoptera Polistes dominula (European paper wasp) and Vespula spp. (yellow jacket).
Toxins 12:323 (2020)
Allergic reactions to stings of Hymenoptera species can have serious or even fatal consequences. If the identification of the culprit insect is possible, venom-specific immunotherapy effectively cures Hymenoptera venom allergies. Although component-resolved diagnostics has strongly evolved in recent years, the differentiation between allergies to closely related species such asPolistes dominulaandVespulaspp. is still challenging. In order to generate the basis for new diagnostic and therapeutic strategies, this study aims at resolving the venom proteomes (venomes) of these species. The venoms ofP. dominulaandVespulaspp. (V. germanica,V. vulgaris) were analyzed by liquid chromatography-mass spectrometry. Resulting proteins were characterized regarding their function, localization and biochemical properties. The analyses yielded 157 proteins inVespulaspp. and 100 inP. dominulavenom; 48 proteins, including annotated allergens, were found in both samples. In addition to a variety of venom trace molecules, new allergen candidates such as icarapin-like protein and phospholipase A2 were identified. This study elucidates the venomes of closely related allergy-eliciting Hymenoptera species. The data indicates that relying on marker allergens to differentiate betweenP. dominulaandVespulaspp. venom allergy is probably insufficient and that strategies using cross-reactive major allergens could be more promising.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Allergen ; Hymenoptera Venom Allergy ; European Paper Wasp ; Polistes Dominulavenom ; Venom Proteome ; Vespulaspp ; Venom ; Yellow Jacket; Component-resolved Diagnosis; Dipeptidyl Peptidase Iv; Polistes-dominulus; Hymenoptera Venom; Molecular-cloning; Crystal-structure; Major Allergens; Mastoparan-b; Antigen 5; Helothermine
e-ISSN
2072-6651
Journal
Toxins
Quellenangaben
Volume: 12,
Issue: 5,
Article Number: 323
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)