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Standardized map of iodine status in Europe.
Thyroid 30, 1346-1354 (2020)
Background: Knowledge about the population's iodine status is important, because it allows adjustment of iodine supply and prevention of iodine deficiency. The validity and comparability of iodine-related population studies can be improved by standardization, which was one of the goals of the EUthyroid project. The aim of this study was to establish the first standardized map of iodine status in Europe by using standardized urinary iodine concentration (UIC) data. Materials and Methods: We established a gold-standard laboratory in Helsinki measuring UIC by inductively coupled plasma mass spectrometry. A total of 40 studies from 23 European countries provided 75 urine samples covering the whole range of concentrations. Conversion formulas for UIC derived from the gold-standard values were established by linear regression models and were used to postharmonize the studies by standardizing the UIC data of the individual studies. Results: In comparison with the EUthyroid gold-standard, mean UIC measurements were higher in 11 laboratories and lower in 10 laboratories. The mean differences ranged from -36.6% to 49.5%. Of the 40 postharmonized studies providing data for the standardization, 16 were conducted in schoolchildren, 13 in adults, and 11 in pregnant women. Median standardized UIC was <100 μg/L in 1 out of 16 (6.3%) studies in schoolchildren, while in adults 7 out of 13 (53.8%) studies had a median standardized UIC <100 μg/L. Seven out of 11 (63.6%) studies in pregnant women revealed a median UIC <150 μg/L. Conclusions: We demonstrate that iodine deficiency is still present in Europe, using standardized data from a large number of studies. Adults and pregnant women, particularly, are at risk for iodine deficiency, which calls for action. For instance, a more uniform European legislation on iodine fortification is warranted to ensure that noniodized salt is replaced by iodized salt more often. In addition, further efforts should be put on harmonizing iodine-related studies and iodine measurements to improve the validity and comparability of results.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Epidemiology ; Iodine ; Iodine Supply ; Method Comparison; Population; Samples
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
1050-7256
e-ISSN
1557-9077
Journal
Thyroid
Quellenangaben
Volume: 30,
Issue: 9,
Pages: 1346-1354
Publisher
Mary Ann Liebert
Publishing Place
140 Huguenot Street, 3rd Fl, New Rochelle, Ny 10801 Usa
Reviewing status
Peer reviewed
Institute(s)
Independent Research Group Clinical Epidemiology (KEPI)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-502900-001
G-504090-001
G-504090-001
WOS ID
WOS:000556900900001
Scopus ID
85090899904
PubMed ID
32460688
Erfassungsdatum
2020-06-02