PuSH - Publication Server of Helmholtz Zentrum München: Predicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy Melanoma brain metastases prognostic score.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Schaule, J.* ; Kroeze, S.G.C.* ; Blanck, O.* ; Stera, S.* ; Kahl, K.H.* ; Roeder, F.* ; Combs, S.E. ; Kaul, D.* ; Claes, A.* ; Schymalla, M.M.* ; Adebahr, S.* ; Eckert, F.* ; Lohaus, F.* ; Abbasi-Senger, N.* ; Henke, G.* ; Szuecs, M.* ; Geier, M.* ; Sundahl, N.* ; Buergy, D.* ; Dummer, R.* ; Guckenberger, M.*

Predicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy Melanoma brain metastases prognostic score.

Radiat. Oncol. 15:135 (2020)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Background Melanoma patients frequently develop brain metastases. The most widely used score to predict survival is the molGPA based on a mixed treatment of stereotactic radiotherapy (SRT) and whole brain radiotherapy (WBRT). In addition, systemic therapy was not considered. We therefore aimed to evaluate the performance of the molGPA score in patients homogeneously treated with SRT and concurrent targeted therapy or immunotherapy (TT/IT). Methods This retrospective analysis is based on an international multicenter database (TOaSTT) of melanoma patients treated with TT/IT and concurrent (<= 30 days) SRT for brain metastases between May 2011 and May 2018. Overall survival (OS) was studied using Kaplan-Meier survival curves and log-rank testing. Uni- and multivariate analysis was performed to analyze prognostic factors for OS. Results One hundred ten patients were analyzed. 61, 31 and 8% were treated with IT, TT and with a simultaneous combination, respectively. A median of two brain metastases were treated per patient. After a median follow-up of 8 months, median OS was 8.4 months (0-40 months). The molGPA score was not associated with OS. Instead, cumulative brain metastases volume, timing of metastases (syn- vs. metachronous) and systemic therapy with concurrent IT vs. TT influenced OS significantly. Based on these parameters, the VTS score (volume-timing-systemic therapy) was established that stratified patients into three groups with a median OS of 5.1, 18.9 and 34.5 months, respectively (p = 0.001 and 0.03). Conclusion The molGPA score was not useful for this cohort of melanoma patients undergoing local therapy for brain metastases taking into account systemic TT/IT. For these patients, we propose a prognostic VTS score, which needs to be validated prospectively.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Molgpa ; Melanoma ; Stereotactic ; Brain Metastases ; Immunotherapy ; Targeted Therapy; Recursive Partitioning Analysis; Radiation-therapy; Open-label; Radiosurgery; Ipilimumab; Multicenter; Diagnosis; Indexes

ISSN (print) / ISBN 1748-717X

e-ISSN 1748-717X

Journal Radiation Oncology

Quellenangaben Volume: 15, Issue: 1, Article Number: 135

Publisher BioMed Central

Publishing Place Campus, 4 Crinan St, London N1 9xw, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Medicine (IRM)