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Elgebaly, H.* ; Germoush, M.* ; Mosa, N.* ; Zahou, F.* ; Soffar, A.* ; Alotaibi, N.* ; Qarmush, M.* ; Hussein, O.* ; Bin-Jumah, M.* ; Hassanein, E.* ; Hernandez-Bautista, R. ; Mahmoud, A.M.*

Adenium obesum flowers extract mitigates testicular injury and oxidative stress in streptozotocin-induced diabetic rats.

Int. J. Pharm. 16, 310-318 (2020)

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	Open Access Gold (Paid Option)

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Background and Objective: Diabetes Mellitus (DM) is a major healthcare problem worldwide and considerable evidence proved its negative impact on the male reproductive system. Adenium obesum is an interesting medicinal plant with a wide range of bioactivities. The current study examined the protective effects of A. obesum flower extract (AOE) on testicular injury in streptozotocin (STZ)-induced type I diabetic rats. Materials and Methods: Diabetes was induced by a single injection of 50 mg kg(-1) STZ. Diabetic rats received 250 and 500 mg kg(-1) AOE for 21 days and samples were collected for analysis. Results: As compared to the diabetic control rats, treatment with AOE increased serum testosterone, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels, decreased testicular thiobarbituric acid reactive substances (TBARS) content, effectively enhanced reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Additionally, AGE effectively inhibited diabetes-induced testicular tissue injuryand prevented inflammatoryand apoptotic responses manifested by decreased TNF-alpha, IL-6 and Bax and increased Bcl-2. Conclusion: These results demonstrated that AGE mitigates testicular injury, oxidative stress, inflammatory response and apoptotic cell death in STZ-induced diabetic rats.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Desert Rose ; Oxidative Injury ; Inflammation ; Antioxidants ; Phenolics ; Diabetes ; Testosterone ; Apoptosis; Germ-cell Death; Mellitus; Inflammation; Damage; Apoptosis; Activation; Protects; Taurine; Roem.

ISSN (print) / ISBN 0378-5173

e-ISSN 1873-3476

Journal International Journal of Pharmaceutics

Quellenangaben Volume: 16, Issue: 4, Pages: 310-318

Publisher Elsevier

Publishing Place Amsterdam

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Obesity (IDO)