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Elgebaly, H.* ; Germoush, M.* ; Mosa, N.* ; Zahou, F.* ; Soffar, A.* ; Alotaibi, N.* ; Qarmush, M.* ; Hussein, O.* ; Bin-Jumah, M.* ; Hassanein, E.* ; Hernandez-Bautista, R. ; Mahmoud, A.M.*

Adenium obesum flowers extract mitigates testicular injury and oxidative stress in streptozotocin-induced diabetic rats.

Int. J. Pharm. 16, 310-318 (2020)
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Background and Objective: Diabetes Mellitus (DM) is a major healthcare problem worldwide and considerable evidence proved its negative impact on the male reproductive system. Adenium obesum is an interesting medicinal plant with a wide range of bioactivities. The current study examined the protective effects of A. obesum flower extract (AOE) on testicular injury in streptozotocin (STZ)-induced type I diabetic rats. Materials and Methods: Diabetes was induced by a single injection of 50 mg kg(-1) STZ. Diabetic rats received 250 and 500 mg kg(-1) AOE for 21 days and samples were collected for analysis. Results: As compared to the diabetic control rats, treatment with AOE increased serum testosterone, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels, decreased testicular thiobarbituric acid reactive substances (TBARS) content, effectively enhanced reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Additionally, AGE effectively inhibited diabetes-induced testicular tissue injuryand prevented inflammatoryand apoptotic responses manifested by decreased TNF-alpha, IL-6 and Bax and increased Bcl-2. Conclusion: These results demonstrated that AGE mitigates testicular injury, oxidative stress, inflammatory response and apoptotic cell death in STZ-induced diabetic rats.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Desert Rose ; Oxidative Injury ; Inflammation ; Antioxidants ; Phenolics ; Diabetes ; Testosterone ; Apoptosis; Germ-cell Death; Mellitus; Inflammation; Damage; Apoptosis; Activation; Protects; Taurine; Roem.
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0378-5173
e-ISSN 1873-3476
Journal International Journal of Pharmaceutics
Quellenangaben Volume: 16, Issue: 4, Pages: 310-318 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30502 - Diabetes: Pathophysiology, Prevention and Therapy
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-508600-014
DOI 10.3923/ijp.2020.310.318
WOS ID WOS:000534611100004
Erfassungsdatum 2020-06-08
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