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Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Nat. Bio. Eng. 4, 801–813 (2020)
Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue.Label-free imaging of the endogenous pigment lipofuscin at near-infrared and shortwave-infrared wavelengths enables the longitudinal monitoring of liver injury in mice and in biopsied human livers.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Sudan Black B; Fibrotic Liver; Fibrosis; Autofluorescence; Macrophages; Myofibroblasts; Epidemiology; Inflammation; Prevalence; Apoptosis
ISSN (print) / ISBN
2157-846X
e-ISSN
2157-846X
Journal
Nature biomedical engineering
Quellenangaben
Volume: 4,
Pages: 801–813
Publisher
Nature Publishing Group
Publishing Place
London ; New York NY ; Tokyo
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)