PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Saif, M.* ; Kwanten, W.J.* ; Carr, J.A.* ; Chen, I.X.* ; Posada, J.M.* ; Srivastava, A.* ; Zhang, J.* ; Zheng, Y.* ; Pinter, M.* ; Chatterjee, S.* ; Softic, S.* ; Kahn, C.R.* ; van Leyen, K.* ; Bruns, O.T. ; Jain, R.K.* ; Bawendi, M.G.*

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Nat. Bio. Eng. 4, 801–813 (2020)
Postprint DOI PMC
Open Access Green
Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue.Label-free imaging of the endogenous pigment lipofuscin at near-infrared and shortwave-infrared wavelengths enables the longitudinal monitoring of liver injury in mice and in biopsied human livers.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
18.952
3.862
11
22
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Sudan Black B; Fibrotic Liver; Fibrosis; Autofluorescence; Macrophages; Myofibroblasts; Epidemiology; Inflammation; Prevalence; Apoptosis
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2157-846X
e-ISSN 2157-846X
Journal Nature biomedical engineering
Quellenangaben Volume: 4, Issue: , Pages: 801–813 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London ; New York NY ; Tokyo
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Pioneer Campus
PSP Element(s) G-510001-001
DOI 10.1038/s41551-020-0569-y
WOS ID WOS:000542072600004
Scopus ID 85086771787
PubMed ID 32572196
Erfassungsdatum 2020-07-08
[➜Report correction]