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Jarosch, I.* ; Schneeberger, T.* ; Gloeckl, R.* ; Kreuter, M.* ; Frankenberger, M. ; Neurohr, C.* ; Prasse, A.* ; Freise, J.* ; Behr, J.* ; Hitzl, W.* ; Koczulla, A.R.* ; Kenn, K.*

Short-term effects of comprehensive pulmonary rehabilitation and its maintenance in patients with idiopathic pulmonary fibrosis: A randomized controlled trial.

J. Clin. Med. 9:1567 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The recommendation for pulmonary rehabilitation (PR) in idiopathic pulmonary fibrosis (IPF) is weak with low-quality evidence. Therefore, the aim of this study is to investigate short-term PR effects and their maintenance after a 3-month follow-up. Fifty-four IPF patients were randomized into a group receiving a 3-week comprehensive, inpatient PR (n = 34, FVC: 74 +/- 19% pred.) or usual care (UC) (n = 17, FVC: 72 +/- 20%pred.). Outcomes were measured at baseline (T1), after intervention (T2), and 3 months after T2 (T3). A 6-min walk distance (6MWD) was used as the primary outcome and chronic respiratory disease questionnaire (CRQ) scores as the secondary outcome. Change in 6MWD from T1 to T2 (Delta = 61 m, 95% CI (18.5-102.4), p = 0.006) but not from T1 to T3 (Delta = 26 m, 95% CI (8.0-61.5), p = 0.16) differed significantly between groups. Higher baseline FVC and higher anxiety symptoms were significant predictors of better short-term 6MWD improvements. For the change in CRQ total score, a significant between-group difference from T1 to T2 (Delta = 3.0 pts, 95% CI (0.7-5.3), p = 0.01) and from T1 to T3 (Delta = 3.5 pts, 95% CI (1.5-5.4), p = 0.001) was found in favour of the PR group. To conclude, in addition to the short-term benefits, inpatient PR is effective at inducing medium-term quality of life improvements in IPF. PR in the early stages of the disease seems to provoke the best benefits.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Pulmonary Rehabilitation ; Idiopathic Pulmonary Fibrosis ; Exercise ; Quality Of Life; Interstitial Lung-disease; Field Walking Tests; Guidelines; Statement; Outcomes; Anxiety
ISSN (print) / ISBN 2077-0383
e-ISSN 2077-0383
Journal Journal of Clinical Medicine
Quellenangaben Volume: 9, Issue: 5, Pages: , Article Number: 1567 Supplement: ,
Publisher MDPI
Publishing Place Basel
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Lung Health and Immunity (LHI)