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Muenchhoff, M.* ; Mairhofer, H.* ; Nitschko, H.* ; Grzimek-Koschewa, N.* ; Hoffmann, D. ; Berger, A.* ; Rabenau, H.* ; Widera, M.* ; Ackermann, N.* ; Konrad, R.* ; Zange, S.* ; Graf, A.* ; Krebs, S.* ; Blum, H.* ; Sing, A.* ; Liebl, B.* ; Wölfel, R.* ; Ciesek, S.* ; Drosten, C.* ; Protzer, U. ; Boehm, S.* ; Keppler, O.T.*

Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020.

Euro Surveill. 25, 2-6 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Containment strategies and clinical management of coronavirus disease (COVID-19) patients during the current pandemic depend on reliable diagnostic PCR assays for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we compare 11 different RT-PCR test systems used in seven diagnostic laboratories in Germany in March 2020. While most assays performed well, we identified detection problems in a commonly used assay that may have resulted in false-negative test results during the first weeks of the pandemic.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Covid-19 ; Diagnostic Test ; Pcr ; Sars-cov-2
ISSN (print) / ISBN 1025-496X
e-ISSN 1560-7917
Journal Eurosurveillance
Quellenangaben Volume: 25, Issue: 24, Pages: 2-6 Article Number: , Supplement: ,
Publisher European Centre for Disease Prevention and Control
Publishing Place Saint-Maurice
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)