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Insulin und sein Rezeptor – Spezifität durch Kombinatorik?
BioSpektrum 26, 369-371 (2020)
Glucose homeostasis and growth essentially depend on insulin engaging its receptor. Combining biochemistry, structural biology, and molecular dynamics simulations, we demonstrated how insulin binding stabilizes the insulin receptor in a T-shaped conformation with up to four bound ligands: two at receptor site 1 and - for the first time - two at site 2. These findings expand the current models of insulin binding to its receptor and potentially inform new approaches to structure-guided drug design.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
german
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Journal
BioSpektrum
Quellenangaben
Volume: 26,
Issue: 4,
Pages: 369-371
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502600-002
Scopus ID
85086831983
Erfassungsdatum
2020-07-16