Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
 |
Open Access Gold (Paid Option) |
|
as soon as is submitted to ZB.
Insulin und sein Rezeptor – Spezifität durch Kombinatorik?
BioSpektrum 26, 369-371 (2020)
Glucose homeostasis and growth essentially depend on insulin engaging its receptor. Combining biochemistry, structural biology, and molecular dynamics simulations, we demonstrated how insulin binding stabilizes the insulin receptor in a T-shaped conformation with up to four bound ligands: two at receptor site 1 and - for the first time - two at site 2. These findings expand the current models of insulin binding to its receptor and potentially inform new approaches to structure-guided drug design.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Journal
BioSpektrum
Quellenangaben
Volume: 26,
Issue: 4,
Pages: 369-371
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)