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A cell in hand is worth two in the embryo: Recent advances in 2-cell like cell reprogramming.
Curr. Opin. Genet. Dev. 64, 26-30 (2020)
Multicellular organisms develop from a single cell, the zygote. This feature is referred to as totipotency. In the mouse, only the zygote and the 2-cell stage embryo display this attribute. Cells resembling the embryonic 2-cell stage blastomeres were identified in embryonic stem (ES) cell cultures as ‘2-cell-like cells’ (2CLCs). This discovery brought the first cellular model with the possibility to investigate some features of the totipotent embryo and the molecular mechanisms regulating totipotency in vitro. In this article, we discuss the latest advancements on the research on 2CLCs, which have uncovered an intricate reprogramming process regulated by proteins as well as metabolites and ncRNAs. These recent findings have shed light on the combinatorial regulation of 2-cell-like cell emergence and the nature of their unique attributes.
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Publication type
Article: Journal article
Document type
Review
Keywords
Activation; Genes; Dux
ISSN (print) / ISBN
0959-437X
e-ISSN
1879-0380
Quellenangaben
Volume: 64,
Pages: 26-30
Publisher
Elsevier
Publishing Place
84 Theobalds Rd, London Wc1x 8rr, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
Grants
long-term EMBO fellowship
German Research Council
Helmholtz Association
German Research Council
Helmholtz Association