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Combined influence of waist and hip circumference on risk of death in a large cohort of European and Australian adults.
J. Am. Heart Assoc. 9:e015189 (2020)
Background Waist circumference and hip circumference are both strongly associated with risk of death; however, their joint association has rarely been investigated.Methods and Results The MONICA Risk, Genetics, Archiving, and Monograph (MORGAM) Project was conducted in 30 cohorts from 11 countries; 90 487 men and women, aged 30 to 74 years, predominantly white, with no history of cardiovascular disease, were recruited in 1986 to 2010 and followed up for up to 24 years. Hazard ratios were estimated using sex-specific Cox models, stratified by cohort, with age as the time scale. Models included baseline categorical obesity measures, age, total and high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive drugs, smoking, and diabetes mellitus. A total of 9105 all-cause deaths were recorded during a median follow-up of 10 years. Hazard ratios for all-cause death presented J- or U-shaped associations with most obesity measures. With waist and hip circumference included in the same model, for all hip sizes, having a smaller waist was strongly associated with lower risk of death, except for men with the smallest hips. In addition, among those with smaller waists, hip size was strongly negatively associated with risk of death, with approximate to 20% more people identified as being at increased risk compared with waist circumference alone.Conclusions A more complex relationship between hip circumference, waist circumference, and risk of death is revealed when both measures are considered simultaneously. This is particularly true for individuals with smaller waists, where having larger hips was protective. Considering both waist and hip circumference in the clinical setting could help to best identify those at increased risk of death.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hip Circumference ; Mortality ; Obesity ; Waist Circumference; Cardiovascular-disease; Fat Distribution; Body-fat; Obesity; Mortality; Ratio; Height; Time; Men
Language
english
Publication Year
2020
HGF-reported in Year
2020
e-ISSN
2047-9980
Quellenangaben
Volume: 9,
Issue: 13,
Article Number: e015189
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-504000-002
G-504090-001
G-504090-001
WOS ID
WOS:000550988200023
Scopus ID
85088209728
PubMed ID
32602397
Erfassungsdatum
2020-07-03