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Gabashvili, A.N.* ; Chmelyuk, N.S.* ; Efremova, M.V. ; Malinovskaya, J.A.* ; Semkina, A.S.* ; Abakumov, M.A.*

Encapsulins-bacterial protein nanocompartments: Structure, properties, and application.

Biomolecules 10:966 (2020)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Recently, a new class of prokaryotic compartments, collectively called encapsulins or protein nanocompartments, has been discovered. The shell proteins of these structures self-organize to form icosahedral compartments with a diameter of 25-42 nm, while one or more cargo proteins with various functions can be encapsulated in the nanocompartment. Non-native cargo proteins can be loaded into nanocompartments and the surface of the shells can be further functionalized, which allows for developing targeted drug delivery systems or using encapsulins as contrast agents for magnetic resonance imaging. Since the genes encoding encapsulins can be integrated into the cell genome, encapsulins are attractive for investigation in various scientific fields, including biomedicine and nanotechnology.
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Publication type Article: Journal article
Document type Review
Keywords Encapsulin ; Nanocompartment ; Cell Labeling ; Mri; Rhodococcus-jostii Rha1; Mycobacterium-tuberculosis; In-vitro; Iron Storage; Virus; Delivery; Identification; Nanoparticles; Ferritin; Esha
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2218-273X
e-ISSN 2218-273X
Journal Biomolecules
Quellenangaben Volume: 10, Issue: 6, Pages: , Article Number: 966 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Developmental Genetics (IDG)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30204 - Cell Programming and Repair
Research field(s) Enabling and Novel Technologies
Genetics and Epidemiology
PSP Element(s) G-505592-001
G-500500-001
DOI 10.3390/biom10060966
WOS ID WOS:000550907300001
Scopus ID 85087418587
PubMed ID 32604934
Erfassungsdatum 2020-07-06
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