PuSH - Publication Server of Helmholtz Zentrum München: Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Tian, X.* ; Li, R.* ; Jiang, Y. ; Zhao, F.* ; Yu, Z.* ; Wang, Y.* ; Dong, Z.* ; Liu, P.* ; Li, X.*

Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake.

J. Funct. Food. 72:104045 (2020)

Publ. Version/Full Text

Research data

DOI

	Open Access Gold (Paid Option)

Abstract
Metrics
Extra information

Gut microbiota has been identified as a key player in the development of alcoholic liver disease (ALD). Targeting gut microbiota with probiotic intervention will be an attractive approach to prevent ALD. Here, we investigated the effects of probiotic Bifidobacterium breve ATCC15700 (ATCC15700) on liver injury and gut microbiota in mice exposed to chronic alcohol intake. Our results showed that oral administration of ATCC15700 significantly decreased endotoxemia, maintained immune homeostasis, and alleviated alcohol-induced liver injury. ATCC15700 also promoted intestinal barrier function by enhancing the expressions of tight junction proteins in alcohol-treated mice. Moreover, analysis of gut microbiota showed that ATCC15700 normalized the structure and composition of the alcohol-disrupted gut microbiota. Correlation between gut microbiota and liver injury parameters revealed that specific bacteria, including S24_7, unclassified Clostridiales, Butyricicoccus, Oscillospira, Ruminococcus, Mucispirillum and unclassified Lachnospiraceae, were predominantly associated with ALD. In conclusion, ATCC15700 protected alcohol-exposed mice against liver injury via modulating gut micobiota.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Bifidobacterium Breve Atcc15700 ; Alcoholic Liver Disease ; Immune Homeostasis ; Inflammation ; Intestinal Barrier Function ; Gut Microbiota; Intestinal Permeability; Aldehyde Dehydrogenase; Mouse Model; Injury; Dysbiosis; Inflammation; Protection; Dependence; Probiotics; Enzymes

ISSN (print) / ISBN 1756-4646

e-ISSN 1756-4646

Journal Journal of Functional Foods

Quellenangaben Volume: 72, Article Number: 104045

Publisher Elsevier

Publishing Place Amsterdam

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)