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Gambichler, T.* ; Reuther, J.* ; Scheel, C. ; Becker, J.C.*

On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19.

J. Immunother. Cancer 8:e001145 (2020)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19. In detail, we provide available information on (1) safety regarding the risk of new infections, (2) effects on the outcome of pre-existing infections, (3) whether immunosuppressive drugs used to treat ICI-related adverse events affect the risk of infection or virulence of pre-existing infections, (4) whether the use of vaccines in ICI-treated patients is considered safe, and (5) whether there are beneficial effects of ICIs that even qualify them as a therapeutic approach for these viral infections.
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Publication type Article: Journal article
Document type Review
Keywords Immune Evation ; Review ; T-lymphocytes ; Tumor Escape ; Vaccination; Progressive Multifocal Leukoencephalopathy; Lung-cancer; Therapy; Immunopathology; Immunotherapy; Exhaustion; Expression; Blockade; Defines
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2051-1426
e-ISSN 2051-1426
Journal Journal for ImmunoTherapy of Cancer
Quellenangaben Volume: 8, Issue: 2, Pages: , Article Number: e001145 Supplement: ,
Publisher Bmj Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500890-001
DOI 10.1136/jitc-2020-001145
WOS ID WOS:000639555700001
WOS ID WOS:000590727000002
Scopus ID 85087532093
PubMed ID 32611687
Erfassungsdatum 2020-07-07
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